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April 2, 2024

CENTELLORY®

CENTELLORY®

Preserves mind and memory for ongoing wellness

A new extract promoting optimal brain functions

The average life expectancy increased by about 25 years over the past century. An ongoing concern is now to preserve the quality of life. Among people who wants to fully enjoy their elderly days, 75 % fear the memory loss and cognitive decline. As the expert in mental balance solutions, GPE created CENTELLORY® to help develop and maintain mind and memory.

CENTELLORY® is an extract from Centella asiatica, also well known in ayurvedic medicine as Gotu kola, characterized by its unique double standardization in polyphenolics and triterpenoids compounds.

0

good reasons
to choose CENTELLORY®

Efficiency

Memory enhancer
Natural mild anxiolytic
Double standardization

Premium Quality

Dual standardization to ensure best efficiency

Only the best raw material quality

Safety

Full traceability control
No adverse effects at the advised dosage

Health Benefit

Cognitive performance

Wound healing

Dual Market Target

Elderly

Youngsters

Anxiety, stress improvement

Anxiety, stress improvement

Memory and learning enhancement

Memory and learning enhacement

Neuroprotective

Neuroprotective

Alertness and calmness improvement for the elderly

Alertness and calmness improvement for the elderly

Mechanism of action

Modulation of nitric oxide
Increases GABA release
Potential regulation of hypothalamo-pituitary-adrenocortical axis
Decreases TNF-α level and increases BDNF level
Increases synaptic density
Increases BDNF concentration in the hippocampus tissue
Increases expression of AMPAR subunits and differential expression of NMDAR subunits
Decreases the levels of amyloid-β
Improves dendritic arborization and synaptic differentiation
Reduces oxidative stress
Restores cholinergic dysfunction by decreasing the acetylcholinesterase level
Prevents the ultrastructural morphological aberrations of neurons

Boosts cognition

Preserves memory

Bibliography:
maintain mind, memory, and brain architecture

Randomized, placebo-controlled, double-blind clinical trial investigated the effect of Centella asiatica on cognitive function with doses 0, 250, 500 and 750 mg once daily for 60 days. Centella asiatica attenuates the age-related decline in cognitive function and mood disorder in elderly.

No Data Found

Figure 1. Effect of Centella asiatica on calmness5
(* significant compared placebo)

No Data Found

  1. Increase of dendritic branching points with Centella asiatica treatment, as compared to the control group
  2. 80% more apical dendrites
  3. 100% more basal dendrites
  4. Basal dendrites

Centella asiatica treatment supports memory formation by increasing the basal and apical dendritic branching in CA3 pyramidal neurons of the hippocampus

Centella asiatica

Technical Data

Commercial name

CENTELLORY®

Description

Centella asiatica aerial part extract

Active compounds

Triterpenoids ≥ 20%
Polyphenolics compounds ≥ 10%

Form

Powder

Recommended dosage

200 mg/day for a 3 to 6 weeks treatment

Application

Food supplements: tablets, capsules, softgel capsules, sachets…

Liquid formulations

Bibliography

1. Chanana P, Kumar A. Possible Involvement of Nitric Oxide Modulatory Mechanisms in the Neuroprotective Effect of Centella asiatica Against Sleep Deprivation Induced Anxiety Like Behaviour, Oxidative Damage and Neuroinflammation. Phytother Res. 2016;30(4):671-80 2. Kumar A CP. Further Investigations on the Neuroprotective Potential of Centella siatica against Sleep Deprivation Induced Anxiety like Behaviour: Possible Implications of Mitoprotective and Anti-Stress Pathways. Journal of Sleep Disorders: Treatment and Care. 2017;06(02) 3. Sari DCR, Arfian N, Tranggono U, Setyaningsih WAW, Romi MM, Emoto N. Centella asiatica (Gotu kola) ethanol extract up-regulates hippocampal brain-derived neurotrophic factor (BDNF), tyrosine kinase B (TrkB) and extracellular signal-regulated protein kinase 1/2 (ERK1/2) signaling in chronic electrical stress model in rats. Iran J Basic Med Sci. 2019;22(10):1218-24 4. Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, et al. Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer’s disease animal model. Phytother Res.2009;23(1):14-9 5. Wattanathorn J, Mator L, Muchimapura S, Tongun T, Pasuriwong O, Piyawatkul N, et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol. 2008;116(2):325-32 6. Wanasuntronwong A, Wanakhachornkrai O, Phongphanphanee P, Isa T, Tantisira B, Tantisira MH. Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233. Evid Based Complement Alternat Med. 2018;2018:3853147 7. U Jana TS, LN Maity, PK Debnath and D Bhattacharyya. A clinical study on the management of generalized anxiety disorder with Centella asiatica. Nepal Med Coll J. 2010 8. Ar Rochmah M, Harini IM, Septyaningtrias DE, Sari DCR, Susilowati R. Centella asiatica Prevents Increase of Hippocampal Tumor Necrosis Factor-alpha Independently of Its Effect on Brain-Derived Neurotrophic Factor in Rat Model of Chronic Stress. Biomed Res Int. 2019;2019:2649281 9. Gray NE, Zweig JA, Caruso M, Martin MD, Zhu JY, Quinn JF, et al. Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice. Brain Behav. 2018;8(7):e01024 10. Wong JH, Muthuraju S, Reza F, Senik MH, Zhang J, Mohd Yusuf Yeo NAB, et al. Differential expression of entorhinal cortex and hippocampal subfields alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors enhanced learning and memory of rats following administration of Centella asiatica. Biomed Pharmacother. 2019;110:168-80 11. Matthews DG, Caruso M, Murchison CF, Zhu JY, Wright KM, Harris CJ, et al. Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice. Antioxidants (Basel). 2019;8(12) 12. Doulah A, Mahmoodi G, Pourmahdi Borujeni M. Evaluation of the pre-treatment effect of Centella asiatica medicinal plants on long-term potentiation (LTP) in rat model of Alzheimer’s disease. Neurosci Lett. 2020;729:135026 13. Rao SB, Chetana M, Uma Devi P. Centella asiatica treatment during postnatal period enhances learning and memory in mice. Physiol Behav. 2005;86(4):449-57

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