SCUTELL'UP®
Enhances your mind's potential
A safe and non addictive anxiolytic
Up to 50% of people around the world feel stressed at least 3 times a week. Conventional pharmaceutical anxiolytic molecules have been linked to undesirable side effects such as tolerance and dependency. Mistrusting those conventional medications, people experiencing medium stress symptoms are looking for safer solutions.
As the expert in mental balance solutions, GPE created SCUTELL’UP® an ingredient to improve mood without sedative effects.
SCUTELL’UP® is an extract from Scutellaria baicalensis rich in flavones with demonstrated anti-stress activities.
good reasons
to choose SCUTELL’UP®
Efficiency
Natural anti-stress
Without sedation
Immediate action
Results in 2 hours No rebound anxiety
No habituation
No rebound anxiety upon cessation
Safety
Full traceability control
No adverse effects
No addiction
Premium quality
Only the best raw material quality
Health benefits
Scutellaria extracts have been clinically proven to enhance mood without reduction in energy or cognition:
- Within 2 hours
- During a 2 weeks daily treatment2, 3
Also, Scutellaria’s flavones have proved to have other benefits such as:
- Reduction in ADHD
- Spontaneous sleep–wake regulation
- Helpful to deal with food & seasonal allergies
Mechanism of action7
Selective partial agonist of GABA α receptors. This action is similar to the benzodiazepine drugs. The selectivity allows a reduction of anxiety without the sedative undesirable effect
Reduction of inflammation and inflammatory cytokines responsible of depressive symptoms
Promotion of neuronal differentiation and growth
A demonstrated biological activity
The level of Corticosterone, the stress hormone, is drastically increased upon a stress condition. In a chronic mild stress context, Scutellaria extract can reverse its effects, acting as efficiently as conventional medication (such as Fluoxetine).
- CMS
- CMS + Fluoxetine
- CMS + Scutellaria
Corticosterone level in plasma after 15 days of Chronic Mild Stress (CMS) in mice3
In addition, Baicalin, the main flavone present in Scutellaria Baicalensis extract, does not cause cognitive impairment or any motor incoordination effects, not even at high concentrations.
No sedative effect
No rebound anxiety
Technical Data
SCUTELL’UP®
Scutellaria baicalensis root extract
Baicalin: ≥ 85%
Powder
20 mg – 1 to 3 times/day
for a 3 to 6 weeks treatment or as needed
Food supplements: tablets, capsules, softgel capsules, sachets…
Liquid formulations
Bibliography
1. Pang et al. 2016, Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers, Clin Drug Investig 2. Brock et al. 2014, American Skullcap (Scutellaria lateriflora): A Randomised, Double-Blind Placebo-Controlled Crossover Study of its Effects on Mood in Healthy Volunteers, Phytother. Res 3. Pao et al. 2012, Three Chinese herbal medicines promote neuroproliferation in vitro, and reverse the effects of chronic mild stress on behavior, the HPA axis, and proliferation of hippocampal precursor cell in vivo, Journal of Ethnopharmacology 4. Zhou et al. 2019, Baicalin regulates the dopamine system to control the core symptoms of ADHD, Molecular Brain 5. Chang et al. 2011, Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep–wake regulation, Journal of Ethnopharmacology 6. Shin et al. 2014, Preventive effects of skullcap (Scutellaria baicalensis) extract in a mouse model of food allergy, Journal of Ethnopharmacology 7. Limanaqi, et al. 2020, « Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea », Antioxidants 8. Wang et al. 2008, GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin, Neuropharmacology
