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Supports urinary health naturally

Clinically proven efficiency: A 36 mg PACs extract to decrease the fixation of Escherichia coli to urinary tract1

A study investigated the uropathogenic Escherichia coli anti-adhesion activity of PACs. Urines samples collected from 32 volunteers were assessed in two separate bioassays in-vitro and one assay in-vivo with Caenorhabditis elegans model.

The mean survival time (LT50) for C. elegans infected by E. coli grown in urine samples collected after cranberry intake was significantly increased to 5-6 days compared to LT50 for strain grown in urine samples collected after placebo intake (3 days) (Figure 1). Bacteria grown in the urine collected from volunteers that consumed cranberry are not able to adhere. Other results indicated significant anti-adhesion activity in urines of individuals consuming the cranberry compared to placebo (Figure 2).

urine sample at 1-6h
urine sample at 24h
Urine samples collected after placebo intake (3 days)
Figure 1
urine sample at 1-6h
urine sample at 24h
Anti-adhesion activity (%)
Anti-adhesion activity (%)
Figure 1


  • A low temperature of drying.
  • Protection of active compounds, especially the PACs.
  • Preservation of integrity and quality of PACs.
DryCare Technology

The importance of the correct method

No Data Found

Carnberry Fruit Juice Dry Extract
Capsules that contain 36 mg of this extract
Health benefits of the Cranberry6-7, 1

Prevents the adhesion of Escherichia coli on urinary tract

Prevents and limits the recurrent UTIs

An extract preventing urinary tract infections

Urinary tract infections (UTIs) are the second most common infection around the world with a strong apparition in women. This disease is caused by colonization in urinary tract by bacteria, the predominant bacteria being Escherichia coli. 25% of women suffer of recurrent UTIs, thus, the prevention is indispensable to limit the 

recurrence of this disease. GPE, expert in ingredients for health care solution, has developed CRAN’BEY®, an extract of Vaccinium macrocarpon standardized in proanthocyanidins (PACs) dosed by European Pharmacopeia, BL-DMAC and HPLC methods to prevents urinary tract infections.

Source of the Cranberry fruit is crucial



American based, specialized in the harvest of cranberries

North America



Vaccinium macrocarpon





High content of proanthocyanidins (PACs) of dimer Type A

Mechanism of action1-5

PACs prevents the adherence of bacteria to uroepithelial cells of the urinary tract. They interfered in the development and aglutination of bacteria and limites the apparition of infection. Then, bacteria are safely flushed from the body.

Cranberry extract standardized 15-20% PACs

1. E. coli
2. P-fimbriae
3. Receptor
4. Ueropithelim

Technical Data

Commercial name



Vaccinium macrocarpon fruits extract




Food supplement: tablets, capsules, microcapsules, syrups, drinks.
Liquid formulations

Available references (recommended dosage)

CRAN’BEY® 60 — Cranberry extract 60% PAC for UTI (144 mg/day)
CRAN’BEY® 50 — Cranberry extract 50% PAC for UTI (196 mg/day)
CRAN’BEY® 40 — Cranberry extract 40% PAC for UTI (240 mg/day)
CRAN’BEY® 30 — Cranberry extract 30% PAC for UTI (309 mg/day)
CRAN’BEY® 25 — Cranberry extract 25% PAC for UTI (360 mg/day)

Global distribution network of CRAN’BEY®


1. Howell, A. B. et al. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis 10, 94, doi:10.1186/1471-2334-10-94 (2010) 2. Howell, A. B. et al. A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochemistry 66, 2281-2291, doi:10.1016/j.phytochem.2005.05.022 (2005) 3. R. Raz, B. C., and M. Dan. Cranberry Juice and Urinary Tract Infection. Clinical Infectious Diseases (2004) 4. Zafriri et al. Inhibitory Activity of Cranberry Juice on Adherence of Type 1 and Type P Fimbriated Escherichia coli to Eucaryotic Cells, Antimicrobial Agents and Chemotherapy (1989) 5. Sobota A.E, Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infections, The Journal of Urology (1984) 6. Gupta, K. et al. Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J Urol 177, 2357-2360, doi:10.1016/j.juro.2007.01.114 (2007) 7. Yatao Liu, M. A. B., Lizabeth Caron, Terri A. Camesano. Role of Cranberry Juice on Molecular- Scale Surface Characteristics and Adhesion Behavior of Escherichia coli. Wiley Periodicals (2005)