Skip to content


Supports emotional well-being naturally

SAFFR’ACTIV® makes the difference: pioneer, efficient & premium quality

SAFFR’ACTIV® is the first saffron extract in Europe used for emotional wellness. It was developed to deliver a high-quality, reliable ingredient to the nutraceutical industry.

GPE guarantees quality and traceability 100% from the origin by partnering with a local saffron harvester and distributor from the region of Khorasan (Iran), where it grows the highest quality saffron.

SAFFR’ACTIV®SAFFR’ACTIV® has many applications with clinical support1-2 including the support of neuronal preservation and mental health. Moreover, the key bioactives found in saffron extracts, similar to SAFFR’ACTIV®, have been proven to positively impact various aspects of women’s health. 


Low drying temperature

Protects key active compounds found in saffron

Preservation of integrity and quality of crocins

Based on bibliography and over 10 years of GPE expertise

No pesticides
No allergens
No adulteration

SAFFR’ACTIV® is also available as an organic ingredient, certified by Ecocert

Our internally developed quantification method to quantify crocins level in saffron extracts has been externally
published to improve existing quantification methods, providing a more reliable and efficient alternative3

  • 100% purity guaranteed
  • Listed in the European Pharmacopeia and French “arrêté plantes”
  • Every stage of the manufacture is subjected to strict quality requirements
  • Superior traceability “QSE commitment” system
  • Ingredient backed by safety studies
  • Recognized by EU legislation as a food ingredient

SAFFR’ACTIV® is a saffron extract rich in active compounds such as safranal, crocins, crocetin and picrocrocins. Crocins and safranal are the main actives of saffron in terms of health benefits4-7.

With a similar mechanism of action to commonly used products, saffron extract exerts its effect by modulating the levels of certain chemicals in the brain, including serotonin and glutamate, without the side effects.

Mechanism of action

The circulation of neurotransmitters in the brain takes place in the synapses. In a normal situation, the neurotransmitters are released into the synaptic cleft and then are received by the postsynaptic neuron. The neurotransmitters are reuptaken and the message continue to circulate.

When there is a dysfunction in brain signaling, such as when a
person faces mental health challenges, neurotransmitters can
become less available.

The SAFFR’ACTIV® allows to inhibit the re-uptake of dopamine, glutamate, and serotonin level in the synapse.
The inhibition maintains their levels in synapses, leading to an upsurge in their levels in the brain which enables the message to move forward.


1 NT is released in the synaptic cleft
2 NT is received by the postsynaptic neuron
3 NT is reuptake
4 Message moves forward


5 Low availability of NT Message does not move forward

How SAFFR’ACTIV® works*

6 Reuptake of NT inhibited by SAFFR’ACTIV®
7 Increase of NT in the synaptic cleft
8 Message moves forward
NT – neurotransmitter

*Crocins inhibit reuptake of norepinephrine and inhibit reuptake of dopamine and serotonin (inhibition maintains their levels in synapses and upsurges their levels in the brain) and increase glutamate levels. While safranal increase the serotonin levels 8-9.

Clinically proven efficiency:
Proprietary results*

Clinical studies, randomized, double blind against placebo performed in over 90 subjects proved to significantly improve the global sleeping quality in 100% of the subjects, helping in falling asleep and allowing to wake up well-rested1.

SAFFR’ACTIV® has been shown to support relaxation and contribute to overall well-being, with findings corroborated by
scientific literature. Additionally, SAFFR’ACTIV® is a natural and safe option for promoting better sleep duration and quality.

Mean score
Time in Bed (TIB) (min.)
SAFFR’ACTIV® has shown an improve of the TiB compared to placebo.
Mean score
LSEQ score (0-100)
SAFFR’ACTIV® provides a gradual improvement on the sleep process quality, in comparison to placebo users who saw a decrease after week 3.
*LSEQ questionnaire is based on a score of 100, the highest the score, the better is the result.
Mean score
Global PSQI score (0-21)
The PSQI* questionnaire improved during this period, proving an overall boost on the quality of the time in bed.
*PSQI questionnaire is based on a total score of 21, the closest to 0, the better is the result.
Mean score
SAFFR’ACTIV® reduced considerably emotional limitation,while improving the physical global score.
SAFFR’ACTIV® tends to increase general health.
Overall, 73% of users were very satisfied with SAFFR’ACTIV®
*Includes objective results.

SAFFR’ACTIV® to help with sleep

and contribute to emotional balance

SAFFR’ACTIV® bioactive compounds such as crocins and safranal contribute to emotional balance, help maintain apositive mood, and benefit those experiencing poor sleep.

Dysregulated sleep can exacerbate stress, creating a negative cycle between poor sleep and mental health that is challenging to break. Additionally, poor sleep can lead to fatigue, attention
deficits and mood instability.

SAFFR’ACTIV® has proven to improve sleep.







SAFFR’ACTIV® is standardized to formally recognized bioactive compounds, ≥3% crocins and ≥2% safranal, via repeatable HPLC and UV test methods, yielding ≥5% bioactive compounds, not including other bioactive compounds that are naturally present in SAFFR’ACTIV®

Technical Data

Active compounds

Bioactive compounds ≥ 5%
(Crocins  3%, Safranal  2%)

Recommended dosage
30 mg/day
Several possible galenic forms to bring a complete answer to customers

Food supplements:
Tablets, capsules, softgels, sachets, sticks, syrup, liquids, spray, strips


Traditional food:
Fruit juices, sweets, ice cream, chewing gums, chocolate, soups and sauces

Available references (Organic available)

SAF 3C L – Aqueous solution

SAF 3C PIM – Powdered extract on maltodextrin carrier

SAF 3C PIM BIO – Powdered extract on BIO (organic) grade

SAF 3C PC – Powdered extract on microcrystalline cellulose (0.4%)


1 Pachikian et al., 2021, Effects of Saffron Extract on Sleep Quality: A Randomized Double-Blind Controlled Clinical Trial, Nutrients
2 Blasco-Fontecilla et al., 2022, Effectivity of Saffron Extract (Saffr’Activ) on Treatment for Children and Adolescents with Attention Deficit/Hyperactivity Disorder (ADHD): A
Clinical Effectivity Study.
3 Suchareau et al., 2021, Improved quantification method of crocins in saffron extract using HPLC-DAD after qualification by HPLC-DAD-MS, food chemistry
4 Talaei et al. 2014, Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: A randomized, double-blind, placebo-controlled, pilot
clinical trial, Journal of Affective Disorders
5 Nikbakht-Jam et al. 2016, Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized,
placebo-controlled clinical trial, European Journal of Integrative Medicine
6 Khalatbari-mohseni et al. 2019, The effects of crocin on psychological parameters in patients under methadone maintenance treatment: a randomized clinical trial,
Substance Abuse Treatment, Prevention, and Policy
7 Tabeshpour et al. 2017, A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum
8 Georgiadou et al., 2012, Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive–compulsive disorder, Neuroscience Letters
9 Ettehadi et al., 2013, Aqueous Extract of Saffron (Crocus sativus) Increases Brain Dopamine and Glutamate Concentrations in Rats, Journal of Behavioral and Brain Science