PROBIOSTRESS®zen
Maintains a relaxed yet sharp mind
A synergistic ingredient addressing the brain-gut axis
According to the World Health Organization, 450 million persons worldwide are suffering from stress, and prevalence of anxiety is very high in many countries¹. During COVID-2019 pandemic, a big number of studies are showing a strong increase of stress and anxiety diseases worldwide².
As an expert in mental balance solutions, GPE has developed PROBIOSTRESS®zen to help relax while keeping high mental performance, without any adverse effects. PROBIOSTRESS®zen is a synergistic ingredient that creates a virtuous cycle within the brain-gut axis. It is a stable blend of Saffron extract (SAFFR’ACTIV®) and two probiotic strains (Lactobacillus reuteri and Bifidobacterium breve) characterized by its unique standardization and formulation.
good reasons
to choose PROBIOSTRESS®zen
Efficiency
Clinically-proven efficiency on relaxation
Premium Quality
Large amount of probiotics 100% pure
Only the best raw material quality
Safety
Full traceability control
No adverse effects
No addiction
Easy to formulate
Proven stability of the combination
Health benefits
Anxiety
Mood and relaxation
Health benefits
Probiotics, Lactobacillus reuteri and Bifidobacterium breve, were scientifically proven to have mental benefits: Clinically proven
Saffron extract has also many effects on mental health:
- Reduction of depression³
- Maintaining cognitive ability⁴
Mechanism of action
Intestinal microbiota is sometimes referred as the second brain because of its great influence on mood notably through the production of brain active metabolites.
Through its action on the brain and on the intestinal microbiota, PROBIOSTRESS®zen regulates the brain-gut axis and creates a virtuous circle towards a relaxed state of mind.
Clinically-proven efficiency
A clinical study evaluated the efficiency of L. reuteri and B. breve in exerting a positive modulation of stress marker in vitro and evaluated the corresponding effect in human5.
A clinical study evaluated the efficiency of SAFFR’ACTIV® on sleep6 and a preclinical trial evaluated the efficacity in anxiety.
Anxiety improvement
SAFFR’ACTIV® has a significant impact on anxiety
Sleep enhancement
SAFFR’ACTIV® significantly increased the time in bed (measured by actigraphy)
Technical Data
PROBIOSTRESS®zen
Saffron extract (SAFFR’ACTIV®) and probiotic bacteria
Crocins (HPLC): 0.9 mg (0.18%)
Lactobacillus reuteri and Bifidobacterium breve: (109) CFU/g
Powder or capsules
Tasteless and fragrance-free
500 mg/day
4 to 6 weeks
Food supplements: capsules, softgel capsules, sachets, etc
Dry applications: cereal bars, dry instant drinks, etc
Bibliography
1. Champié et al., Probiotic formula: To address physical and psychological symptoms of stress, Nutrafoods, 2011, 10(1) 13-17
2. Vahratian et al., Symptoms of Anxiety or Depressive Disorder and Use of Mental Health Care Among Adults During the COVID-19 Pandemic — United States, August 2020–February 2021, Morbidity and Mortality Weekly Report, 2021
3. Jelodar et al., Saffron improved depression and reduced homocysteine level in patients with major depression: A Randomized, double-blind study, Avicenna J Phytomed, 2018; 8 (1): 43-50
4. Akhondzadeh et al., Saffron in the treatment of patients with mild to moderate Alzheimer’s disease: a 16-week, randomized and placebo- controlled trial, Journal of Clinical Pharmacy and Therapeutics (2010) 35, 581–588
5. Nobile et al., The Effect of a Probiotic Complex on the Gut-Brain Axis: A Translational Study, Neuropsychobiology, 2021
6. Pachikian et al., Effects of Saffron Extract on Sleep Quality: A Randomi- zed Double-Blind Controlled Clinical Trial, Nutrients 2021, 13, 1473
